Research supported by Life Extension has documented the value of nutritional compounds in extending life span and in protecting cells against ischemia (lack of blood flow). Ischemia is the leading cause of disability and death. Ischemia can be caused by the blockage of a coronary artery, which can lead to a heart attack, or a cerebral artery, which can lead to a stroke. Accident victims often die from ischemia. Life Extension supports a full time research facility that has broken all world records in protecting against ischemia-induced free radical damage.